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Fallout 76 is a game filled with challenging enemies, harsh environments, and intricate quests that keep players on their toes. Whether you're exploring the irradiated Appalachian landscape solo or with friends, having the right items in your inventory can make all the difference when completing the main story missions. Below, we’ll go over the 10 best Fallout 76 items that are essential for progressing through the story.

1. Power Armor

Power Armor is a staple in Fallout 76. It provides unparalleled protection and makes a huge difference in both combat and survivability. Whether you’re tackling tough enemies or exploring high-radiation zones, having a full set of Power Armor will increase your chances of survival. There are various types of Power Armor in the game, each with different stats and bonuses, so it's a good idea to keep an eye out for upgrades.

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2. Anti-Armor Weapons

Anti-Armor weapons are highly effective in Fallout 76, particularly when facing enemies with tough armor. These weapons bypass a portion of the target's armor, making them great for both PvE and PvP combat. Weapons like the Anti-Armor Gatling Gun or Anti-Armor Plasma Rifle can help you deal significant damage to the toughest enemies in the game.

3. Stimpaks

Stimpaks are a must-have in your inventory for healing during combat. With Fallout 76’s tough enemies and unpredictable world, you never know when you’ll need a quick boost of health. Always carry a stack of Stimpaks, and don’t forget to stock up on them at vendors or in your stash. They’re lifesavers, especially when you're on a difficult mission or fighting a powerful boss.

4. RadAway

Exposure to radiation is one of the many dangers in the wasteland. RadAway is your go-to item for dealing with radiation poisoning. When completing the main story, you'll often find yourself entering irradiated areas or fighting enemies that cause radiation damage. Keeping a good supply of RadAway in your inventory will allow you to venture further into dangerous zones without worrying about your health.

5. Custom Mods

While mods don’t necessarily appear as standard “items,” they are crucial for enhancing your weapons and armor. Custom mods can improve weapon accuracy, reduce recoil, or increase damage resistance, allowing you to tailor your equipment to better suit your playstyle. Acquiring mods to upgrade your gear is essential for handling the game’s more difficult areas, especially during the main story's challenging sections.

6. Chems (e.g., Buffout, Psycho, and Stealth Boy)

Chems are consumables that provide a variety of boosts to your character’s stats. Whether you're looking to increase your health, carry weight, or damage resistance, chems can give you the edge you need. Buffout boosts strength and endurance, Psycho increases damage dealt, and the Stealth Boy makes you temporarily invisible. These items are especially helpful when completing challenging quests or taking on powerful bosses.

7. Fallout 76 Fusion Core

Fusion Cores are an essential item if you're using Power Armor. These items power your suit, and without them, your Power Armor will be useless. Make sure to keep an eye on your Fusion Core levels and stock up on extra cores when you can. They’re often found in various locations or can be purchased, so be prepared for extended Power Armor use.

8. Legendary Items

Legendary items are high-tier gear with special effects that can dramatically improve your performance. Whether it's a weapon that deals more damage or armor that grants additional bonuses, legendary items make a big difference. These items are often rare, but they are invaluable for progressing through the game’s more difficult sections. If you find yourself struggling, you can always check out Fallout 76 items for sale to grab a Legendary item that suits your needs.

9. Food and Drink (e.g., Nuka-Cola and Radroach Meat)

Food and drink items provide various buffs and help you stay healthy as you explore the wasteland. Nuka-Cola can increase your Action Points, while Radroach Meat can restore your health. Having a good stockpile of food and drink is important to maintain your health, especially when you're out in the wild and don’t have access to medical supplies.

10. Camp Shelter and Decorations

While not directly related to combat, your Camp Shelter plays a vital role in the story. It’s where you can rest, craft, store items, and manage your inventory. You can also decorate your shelter with various items to improve its functionality. Make sure your Camp is well-stocked and organized to make your Fallout 76 experience smoother.

With these 10 best Fallout 76 items, you’ll be well-equipped to tackle the main story missions and survive the harsh world of Appalachia. From Power Armor and anti-armor weapons to healing items like Stimpaks and RadAway, having the right gear can give you a significant advantage. And if you need to save time, remember you can Buy Fallout 76 Items For Sale to stock up on some of the best gear available. Stay prepared, keep your supplies stocked, and you’ll be well on your way to completing the main story!

Bonus Info: List of Fallout 76 Serums